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  • Published in DAO Deficiency

Source: Journal of Neuroinmmunology -November 2013.   A few days ago, the ‘Journal of Neuroinmunology’ published an interesting article titled “A focus on mast cells and pain” written by Dr Anne Héron, of the University of Paris, highlighting histamine role in pain regulation and modulation.

Mast cells (MC) are immune cells with secretory functions that act locally in peripheral tissues to modulate local hemodynamic, nocieptor activation and pain.  They can also infiltrate in the central nervous system (CNS), especially in the spinal cord and thalamus, but their brain function remains an enigma. A regulation role in the opening of the blood-brain barrier has been attributed.

This review paper addresses the mechanism of the endogenous histamine released by mast cells, and highlights the histamine's role as vasodilator mediator that actives neurons and subsequently modulates pain at CNS level. Despite the fact that people with DAO Deficiency accumulate histamine mainly due to a metabolic disorder and, to a lesser extent, to endogenous release, the pain modulation mechanism after histamine accumulation is similar.

A-focus-on-mast-cells-and-pain

   

Histamine as vasodilator mediator that actives neurons and subsequently modulates pain at CNS level. (Journal of Neuroinmmunology – Volume 264)

 Access to full article: http://www.deficitdao.org/es/investigacion.php#.UpR9M8RdDTo

Source: Journal of Neuroinmmunology – Volume 264, Issues 1-2; 15 November 2013, Pages 1-7  Copyright © 2013 Elsevier B.V

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