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DEFICIENCY OF FUNCTIONAL DAO ACTIVITY

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ACCUMULATION OF HISTAMINE, how does it affect us? How to treat it

Source: Journal “Médicos y Medicinas”, January 2012. Every food contains nutritive substances that require a proper metabolism since they enter the oral cavity. The digestive organs carry out the digestion of food thanks to digestive enzymes, obtaining the nutrients required for the proper functioning of the organism.

Histamine is a vital biogenic amine necessary for life. It is a biogenic amine formed in food by action of the microorganism enzymes from amino acids precursors.
Histamine, that is present in every food (of animal and plant origin) in different amounts, should be metabolized in order to be eliminated by urine out problems.

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Enzyme deficiency in bowel as the main cause of migraine

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12th September, European Migraine Day of Action

Europapress, 12th September 2012. 15% of European population suffers migraine, a pathology that affects the social, family and working life of patients, causing in Europe a loss of 20 million of working days per year which is equal to 27 million euros per year.

According to a study of the Neurology Department of Capio Hospital General de Catalunya, the 95% of migraine sufferers has a deficiency of the enzyme called Diamine Oxidase (DAO).  The study led by the neurologist Dr. Joan Izquierdo, head of the Headache Unit of CapioHospital General de Catalunya,  has been awarded by the Catalan Society of Neurology and published in August in the last issue of “Revista de Neurología” magazine.  This research is promoted by DR Healthcare, a laboratory based in Barcelona. Recently, the Physicians’ College of Barcelona has gone into partnership with DR Healthcare to support its research in functional biology and genomics. 

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DAO deficiency, a syndrome that can explain the origin of many of the most common digestive and neurological manifestations

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Migraine and different digestive disorders, according to several clinical studies, are symptoms caused by this enzymatic deficiency in the bowel, which affects 20% of the population

Europapress 27th March, 2014 – Experts in neurology and gastroenterology have presented the results of three clinical studies, in Infarma Madrid 2014, which suggest that Diamine Oxidase deficiency should be considered a syndrome presenting digestive manifestations (such as constipation, abdominal pain or diarrhoea) and neurological manifestations (as migraine), all of them difficult to treat up to now.

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